CARTIHEAL^◊ AGILI-C^◊ Cartilage Repair Implant

A new option for knee cartilage repair

The CARTIHEAL AGILI-C Cartilage Repair Implant is designed to repair damaged cartilage and bone in the knee. A recent study showed that patients treated with the CARTIHEAL AGILI-C implant experienced significant relief of knee pain.¹

In the past, there have been few options to treat damaged articular cartilage. It doesn’t heal well on its own and can cause significant pain.²

The CARTIHEAL AGILI-C implant is a new treatment option. It’s designed to help the body regrow healthy cartilage and heal damaged bone in the knee.^1,3-6 In a recent study, patients who were treated with the CARTIHEAL AGILI-C implant experienced significant and meaningful relief of knee pain. In fact, patients who were treated with the CARTIHEAL AGILI-C implant reported twice the improvement in their knee pain as patients treated with other methods (debridement and microfracture).¹

How it works

Treatment with the CARTIHEAL AGILI-C implant involves a surgical procedure. These are the typical steps:

	Your surgeon makes an incision and identifies the damage to your knee cartilage.
	Your surgeon creates a small hole to remove the damaged tissue.
	Your surgeon places the CARTIHEAL AGILI-C implant into the hole. The implant is made of calcium carbonate and serves as a “scaffold” for new tissue growth.
	Your body begins to replace the implant with new cartilage and bone.4,5
	Within 12-24 months, your body has completely replaced the implant with new tissue. The original implant has been resorbed.4,5

To learn more about the CARTIHEAL AGILI-C Cartilage Repair Implant, talk to an orthopedic surgeon.

References

* Debridement and microfracture

1. Altschuler N, Zaslav KR, Di Matteo B, et al. Aragonite-Based Scaffold Versus Microfractures and Debridement for the Treatment of Knee Chondral and Osteochondral Lesions: Results of a Multicenter Randomized Controlled Trial. Am J Sports Med. 2023;51(4):957-967.
2. Krych AJ, Saris DBF, Stuart MJ, Hacken B. Cartilage injury in the knee: assessment and treatment options. J Am Acad Orthop Surg. 2020;28(22):914-922.
3. Matta C, Szűcs-Somogyi C, Kon E, et al. Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells is enhanced by an aragonite scaffold. Differentiation. 2019;107:24-34.
4. Chubinskaya S, Di Matteo B, Lovato L, Iacono F, Robinson D, Kon E. Agili-C implant promotes the regenerative capacity of articular cartilage defects in an ex vivo model. Knee Surg Sports Traumatol Arthrosc. 2019;27(6):1953-64.
5. Kon E, Filardo G, Shani J, et al. Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model. J Orthop Surg Res. 2015;10:81.
6. Agili-C [package insert]. Kfar Saba, Israel: CartiHeal Inc.; 2021.

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All information provided on this website is for information purposes only. Every patient's case is unique and each patient should follow his or her doctor's specific instructions. Please discuss nutrition, medication and treatment options with your doctor to make sure you are getting the proper care for your particular situation. If you are seeking this information in an emergency situation, please call 911 and seek emergency help.

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